FemtoFiber ultra 1050
Femtosecond fiber laser
Simplifying multi-photon microscopy with stress-less femtosecond lasers
FemtoFiber ultra 1050
Femtosecond fiber laser
In two-photon microscopy, peak-power is brightness! If you care for the best image brightness, you need short pulses, high power, and most importantly a clean temporal pulse shape. The FemtoFiber ultra 1050 features the highest peak power available on the market and hence enables unmatched image brightness.
Additionally, software-controlled dispersion precompensation (GDD) and an integrated AOM for power modulation, make the system extremely user-friendly.
TOPTICA's robust & reliable fiber laser technology significantly reduces the cost of ownership of your laser systems.
The FemtoFiber ultra 1050 is ideally suited for the two-photon excitation of common fluorophores like mCherry, Propidium Iodide, tdTomato, eYFP, DsRed, mRFP or mOrange.
Your Benefits
Compact & Low cost of ownership
Saving table space with all-integrated robust fiber laser system.
Clean Pulse Technology
TOPTICA’s unique Clean Pulse Technology provides clean, pedestal-free pulses even after the fiber for best image brightness.
Images by Shau Poh Chong and Peter Török
User-friendly GDD
Short pulses and software-controlled dispersion precompensation (GDD) for user-friendly handling TOPTICA’s FemtoFiber ultra provides motorized group delay dispersion (GDD) pre-compensation that can be controlled in software. Due to chromatic dispersion, a femtosecond pulse stretches in time when transmitted through optical material in the microscope. GDD pre-compensation adds the opposite dispersion to circumvent this effect by cancelling it out. TOPTICA’s software-controllable GDD pre-compensation ensures short pulses at the sample plane with user-friendly, repeatable optimization of fluorescence signal strength via the graphical user-interface (GUI).
Fast power control
An integrated acousto-optic modulator (AOM) enables fast power-modulation and flyback blanking in synchronization with the beam scanner. This minimizes sample damage and photo-bleaching. Also, a fast electronic trigger output is available as reference for TCSPC in FLIM and gated detection.
For all important fluorophores
The FemtoFiber ultra 1050 is ideally suited for the two-photon excitation of common fluorophores like RFP, mCherry, Propidium Iodide, tdTomato, eYFP, DsRed, mOrange, auto-fluorescence or SHG-imaging.
More than 20 years of experience
TOPTICA is drawing upon 20 years of experience in developing OEM-class fiber lasers. We have tailored our FemtoFiber ultra series to provide our customers with an industrial-grade light engine for high-end applications. The reliable and compact laser design provides femtosecond pulses with high average power, excellent temporal and spatial beam quality.
Options
Pulse picker
An integrated pulse picker reduces the effective repetition rate from 80 MHz to 8 MHz (1:10).
Custom repetition rate
The custom repetition rate provides a modified oscillator with a pre-defined repetition rate between 40 and 80 MHz upon ordering.
Dual-color
With the FemtoFiber ultra dual-color option two FemtoFiber ultra are optically synchronized and allow simultaneous imaging with two different laser colors.
No laser wavelength tuning is required.
FemtoFiber ultra 525
The system has an additional SHG unit that can generate femtosecond pulses with an average power of > 0.5 or > 1 W at 525 nm.
Specifications
Literature
Papers
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A cortical basis for perception of internal gut sensations
Omer Rafael, Stav Shtiglitz, Juliet Miller, Yael Prilutski, Itay Talpir, Ayal Lavi, Yoav Livneh, bioRxiv 2026.02.11.705298; (February 2026) -
Feedforward and feedback population dynamics during binocular conflict in mouse visual cortex
Melina Timplalexi, William M. Connelly, Adam Ranson, bioRxiv 2025.10.02.679998 (October 2025) -
The functional organisation of retrosplenial feedback to V1
Melina Timplalexi, Pedro Mateos-Aparicio, William M. Connelly, Adam Ranson, bioRxiv 2025.09.25.678583 (September 2025) -
From perception to valence: a pair of interneurons that assign positive valence to sweet sensation in Drosophila
Kevin William Christie, Tarandeep Singh Dadyala, Phuong Chung, Masayoshi Ito, Lisha Shao, bioRxiv 2025.10.31.685871 (November 2025) -
Sponges as bioindicators for microparticulate pollutants?
(2021) -
Spectral pulse shaping of a 5 Hz, multi-joule, broadband optical parametric chirped pulse amplification frontend for a 10 PW laser system
František Batysta et al. in Optics Letters (2018)
Articles
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Simplifying two-photon microscopy
Wiley Analytical Science -
Automated femtosecond fiber delivery for multiphoton microscopy
Laura Lohr and Joseph Mastron et al. in Proc. SPIE Paper 13856-12, Multiphoton Microscopy in the Biomedical Sciences XXVI, Conference 13856 (2026) -
Femtosecond fiber delivery at 920 nm for two-photon microscopy
Konrad Birkmeier, et al. in Proc. SPIE 12847, Multiphoton Microscopy in the Biomedical Sciences XXIV, 1284703 (March 2024) -
Faserlaser für die Spektroskopie
M. Breuer et al. in Best of Physik Journal (2017)
Application Notes
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Next generation two-photon microscopy using the FemtoFiber ultra 920 fiber laser
Dr. Max Eisele, Bernhard Wolfring (2019) -
Time-resolved microscopy and spectroscopy using asynchronously synchronized fiber lasers
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Setting Up a Simple and Cost-Efficient Two-Photon Microscope for Neuroscience
Max Eisele -
Automated Femtosecond Fiber Delivery for Multiphoton Microscopy, Webinar
Luisa Hofmann, BioPhotonics (2025)